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The Centre for Spinal Studies and Surgery (CSSS) places a great importance on both clinical and basic research, striving for constant improvement and development.

Several of our consultants actively take part in research with a dedicated team of research fellows that are active in the consultant's field of interest and a specialised team supporting the administrative needs of the department's clinical trials. 

Below is a list of closed clinical trials undertaken by the CSSS in recent years:


TOPS System Post Marketing Evaluation

This study, sponsored by Premia Spine was a single-arm post-marketing evaluation for improvement in function and pain for lumbar spinal stenosis and spondylolisthesis with the TOPS System.




Hydronephrosis After Anterior Lumbar Interbody Fusion (ALIF)

The aim of this study, sponsored by Nottingham University Hospitals NHS Trust, is to identify whether hydronephrosis after Anterior Lumbar Interbody Fusion (ALIF) is complication, in order to bring this to the attention of health care professionals when considering this kind of surgery.




Primary Tumor Retrospective

Amulti-center retrospective cohort study with a cross-sectional survival check sponsored by AOSpine to determine what variables (clinical, diagnostic, therapeutic, or demographic) are associated with local recurrence and survival within defined groups of primary malignant and benign bone and soft tissue spine tumours.




OsseoFix Study


An evaluation of safety and effectiveness of the OsseoFix spinal fracture reduction system, designed by Alphatec Spine, in treating spinal compression fractures.




SSWLI - Spinal Surgery Without Laboratory Investigations


The purpose of this study is to determine the safety and appropriateness of performing minor spinal interventions without laboratory investigations and whether or not a patient requires blood tests post-operatively (until discharge from hospital) and why these tests were required.




STRIVE - STaphylococcus aureus SuRgical Inpatient Vaccine Efficacy

Image result for pfizer logo

A phase 2b, randomised, double-blind, placebo-controlled study, sponsored by Pfizer, to evaluate the safety and efficacy of staphylococcus aureus 4-antigen vaccine (SA4Ag) in adults undergoing elective posterior instrumented lumbar spinal fusion procedures. 



If you wish for the Centre for Spinal Studies and Surgery to become involved on a future or ongoing trial, please do not hesitate to contact the centre's Research Team at:

 Last updated: January 2018