The Centre for Spinal Studies and Surgery (CSSS) places a great importance on both clinical and basic research, striving for constant improvement and development.
Several of our consultants actively take part in research with a dedicated team of research fellows that are active in the consultant's field of interest and a specialised team supporting the administrative needs of the department's clinical trials.
Below is a list of closed clinical trials undertaken by the CSSS in recent years:
NERVES
NERVES is a randomised controlled trial, funded by the National Institute for Health Research's (NIHR) Health Technology Assessment Programme and sponsored by The Walton Centre NHS Foundation Trust, to compare the clinical and cost effectiveness of transforaminal epidural steroid injection to surgical microdiscectomy for treatment of sciatica caused by a prolapsed intervertebral disc.
Scoli-Risk-1
The Scoli-Risk-1 database is a prospective, international, observational, multicentre study, run by the AO Clinical Investigation and Documentation group on behalf of AOSpine and the Scoliosis Research Society.
SCI-POEM - European Multicenter Study
SCI-POEM, sponsored by AOSpine, is a far-reaching study comprising of 17 clinics in 12 countries all across Europe.
The objective of the study is to evaluate if decompressive spinal surgery occurring within 12 hours (post-injury) of a traumatic spinal cord injury can provide superior neurological motor outcomes when compared to late decompression occurring more that 12 hours (and within 14 days) of the injury.
GSTSG Global Spinal Tumour Registry
This study is a prospective analysis of all consenting patients who undergo spinal surgery for metastatic spine disease in surgical units in the UK, Japan, Germany, France, Italy and Denmark. Patient data will be stored on a secure UK database, and analysed by the chief investigator, to determine factors which are associated with good and bad patient outcomes, determine the usefulness of different surgical techniques, and suggest prognostic indicators which will influence future patient management.
TOPS System Post Marketing Evaluation
This study, sponsored by Premia Spine was a single-arm post-marketing evaluation for improvement in function and pain for lumbar spinal stenosis and spondylolisthesis with the TOPS System.
Hydronephrosis After Anterior Lumbar Interbody Fusion (ALIF)
The aim of this study, sponsored by Nottingham University Hospitals NHS Trust, is to identify whether hydronephrosis after Anterior Lumbar Interbody Fusion (ALIF) is complication, in order to bring this to the attention of health care professionals when considering this kind of surgery.
Primary Tumor Retrospective
Amulti-center retrospective cohort study with a cross-sectional survival check sponsored by AOSpine to determine what variables (clinical, diagnostic, therapeutic, or demographic) are associated with local recurrence and survival within defined groups of primary malignant and benign bone and soft tissue spine tumours.
OsseoFix Study
An evaluation of safety and effectiveness of the OsseoFix spinal fracture reduction system, designed by Alphatec Spine, in treating spinal compression fractures.
SSWLI - Spinal Surgery Without Laboratory Investigations
The purpose of this study is to determine the safety and appropriateness of performing minor spinal interventions without laboratory investigations and whether or not a patient requires blood tests post-operatively (until discharge from hospital) and why these tests were required.
STRIVE - STaphylococcus aureus SuRgical Inpatient Vaccine Efficacy
A phase 2b, randomised, double-blind, placebo-controlled study, sponsored by Pfizer, to evaluate the safety and efficacy of staphylococcus aureus 4-antigen vaccine (SA4Ag) in adults undergoing elective posterior instrumented lumbar spinal fusion procedures.
If you wish for the Centre for Spinal Studies and Surgery to become involved on a future or ongoing trial, please do not hesitate to contact the centre's Research Team at: spinalresearch@nuh.nhs.uk
Last updated: November 2019